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Title:

Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases.

Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Trepotec, Zeljka; Lichtenegger, Eva; Plank, Christian; Aneja, Manish K; Rudolph, Carsten
Abstract:
Promising improvements in the field of transcript therapeutics have clearly enhanced the potential of mRNA as a new pillar for protein replacement therapies. Synthetic mRNAs are engineered to replace mutated mRNAs and to be immunologically inconspicuous and highly stable while maximizing protein expression. Approaches to deliver mRNA into the cellular cytoplasm safely and efficiently have been further developed so that two mRNA-based approaches replacing vascular endothelial growth factor (VEGF)...     »
Journal title abbreviation:
Mol Ther
Year:
2019
Journal volume:
27
Journal issue:
4
Pages contribution:
794-802
Fulltext / DOI:
doi:10.1016/j.ymthe.2018.12.012
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30655211
Print-ISSN:
1525-0016
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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