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Titel:

Functional disparities within the TIMP family in cancer: hints from molecular divergence.

Dokumenttyp:
Review; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Autor(en):
Eckfeld, Celina; Häußler, Daniel; Schoeps, Benjamin; Hermann, Chris D; Krüger, Achim
Abstract:
The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases. However, clinical and recent functional studies indicate that some of them correlate with bad prognosis and contribute to the progression of cancer and metastasis, pointing towards mechanisms beyond inhibition of cancer-promoting proteases. Indeed, it is increasingly recognized that TIMPs are multi-functional proteins m...     »
Zeitschriftentitel:
Cancer Metastasis Rev
Jahr:
2019
Band / Volume:
38
Heft / Issue:
3
Seitenangaben Beitrag:
469-481
Volltext / DOI:
doi:10.1007/s10555-019-09812-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31529339
Print-ISSN:
0167-7659
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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