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Title:

Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Document type:
Journal Article
Author(s):
Matthias, Julia; Maul, Julia; Noster, Rebecca; Meinl, Hanna; Chao, Ying-Yin; Gerstenberg, Heiko; Jeschke, Florian; Gasparoni, Gilles; Welle, Anna; Walter, Jörn; Nordström, Karl; Eberhardt, Klaus; Renisch, Dennis; Donakonda, Sainitin; Knolle, Percy; Soll, Dominik; Grabbe, Stephan; Garzorz-Stark, Natalie; Eyerich, Kilian; Biedermann, Tilo; Baumjohann, Dirk; Zielinski, Christina E
Abstract:
The incidence of allergic diseases has increased over the past 50 years, likely due to environmental factors. However, the nature of these factors and the mode of action by which they induce the type 2 immune deviation characteristic of atopic diseases remain unclear. It has previously been reported that dietary sodium chloride promotes the polarization of T helper 17 (TH17) cells with implications for autoimmune diseases such as multiple sclerosis. Here, we demonstrate that sodium chloride also...     »
Journal title abbreviation:
Sci Transl Med
Year:
2019
Journal volume:
11
Journal issue:
480
Fulltext / DOI:
doi:10.1126/scitranslmed.aau0683
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30787167
Print-ISSN:
1946-6234
TUM Institution:
Institut für Virologie ; Klinik und Poliklinik für Dermatologie und Allergologie; Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich); Roman Herzog Comprehensive Cancer Center
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