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Title:

Influence of osteogenic stimulation and VEGF treatment on in vivo bone formation in hMSC-seeded cancellous bone scaffolds.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lenze, Ulrich; Pohlig, Florian; Seitz, Sebastian; Ern, Christina; Milz, Stefan; Docheva, Denitsa; Schieker, Matthias
Abstract:
Tissue engineering approaches for reconstruction of large bone defects are still technically immature, especially in regard to sufficient blood supply. Therefore, the aim of the present study was to investigate the influence of osteogenic stimulation and treatment with VEGF on new bone formation and neovascularization in hMSC-loaded cancellous bone scaffolds in vivo.Cubic scaffolds were seeded with hMSC and either cultured in stem cell medium or osteogenic stimulation medium. One osteogenically...     »
Journal title abbreviation:
BMC Musculoskelet Disord
Year:
2014
Journal volume:
15
Pages contribution:
350
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2474-15-350
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25323565
Print-ISSN:
1471-2474
TUM Institution:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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