Two approaches-one phenomenon-thrombocytopenia after surgical and transcatheter aortic valve replacement.

Vogt, Ferdinand; Moscarelli, Marco; Pollari, Francesco; Kalisnik, Jurij M; Pfeiffer, Steffen; Fittkau, Matthias; Sirch, Joachim; Pförringer, Dominik; Jessl, Jürgen; Eckner, Dennis; Ademaj, Fadil; Bertsch, Thomas; Langhammer, Christian; Fischlein, Theodor; Santarpino, Giuseppe

doi:10.1111/jocs.14547

journal article

Title:: Two approaches-one phenomenon-thrombocytopenia after surgical and transcatheter aortic valve replacement.
Document type:: Article; Journal Article
Author(s):: Vogt, Ferdinand; Moscarelli, Marco; Pollari, Francesco; Kalisnik, Jurij M; Pfeiffer, Steffen; Fittkau, Matthias; Sirch, Joachim; Pförringer, Dominik; Jessl, Jürgen; Eckner, Dennis; Ademaj, Fadil; Bertsch, Thomas; Langhammer, Christian; Fischlein, Theodor; Santarpino, Giuseppe
Abstract:: BACKGROPUND AND AIM: Postoperative thrombocytopenia after surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) and aggravating causes were the aim of this retrospective study. METHODS: Data of all patients treated with SAVR (n = 1068) and TAVR (n = 816) due to severe aortic valve stenosis was collected at our center from 2010 to 2017. Preprocedural and postprocedural values were collected from electronic patient records. RESULTS: There was a significant drop in platelets in both groups, the TAVR group showed overall superior platelet preservation compared to the AVR group (P < .001). In the SAVR subgroup analysis, a significant difference in platelet preservation was observed between the valve types (P < .001), particularly with the Freedom SOLO valve. In the TAVR subgroup analysis, the valve type did not influence platelet count (PLT) reduction (P = .13). In the SAVR subgroup analyses, PLT was found to be worsened with cardiopulmonary bypass (CPB) duration. CONCLUSION: Thrombocytopenia frequently occurs after implantation of a biological heart valve prosthesis, with a higher frequency observed in patients after cardiac surgery rather than TAVR. Although some surgical bioprosthetic models are more susceptible to this phenomenon, CPB duration seems to be a major determinant for the development of postoperative thrombocytopenia.
Journal title abbreviation:: J Card Surg
Year:: 2020
Journal volume:: 35
Journal issue:: 6
Pages contribution:: 1186-1194
Fulltext / DOI:: doi:10.1111/jocs.14547
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/32349178
Print-ISSN:: 0886-0440
TUM Institution:: Klinik und Poliklinik für Unfallchirurgie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Unfallchirurgie (Prof. Biberthaler)2020