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- Document type:
- Article; Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Toman, Ondřej; Hnatkova, Katerina; Smetana, Peter; Huster, Katharina M; Šišáková, Martina; Barthel, Petra; Novotný, Tomáš; Schmidt, Georg; Malik, Marek
- Title:
- Physiologic heart rate dependency of the PQ interval and its sex differences.
- Abstract:
- On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 ± 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 ± 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 ± 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 ± 81.1 vs 65.4 ± 64.3 seconds, respectively, p < 0.00001). P wave duration was even less rate dependent than the PQ interval (9 ± 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 ± 8.4 vs 110.2 ± 7.9 ms, p < 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.
- Journal title abbreviation:
- Sci Rep
- Year:
- 2020
- Journal volume:
- 10
- Journal issue:
- 1
- Fulltext / DOI:
- doi:10.1038/s41598-020-59480-8
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32054960
- Print-ISSN:
- 2045-2322
- TUM Institution:
- I. Medizinische Klinik und Poliklinik (Kardiologie)
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