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Title:

Intrinsic alterations in peripheral neutrophils from cystic fibrosis newborn piglets.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bréa, Déborah; Soler, Laura; Fleurot, Isabelle; Melo, Sandrine; Chevaleyre, Claire; Berri, Mustapha; Labas, Valérie; Teixeira-Gomes, Ana-Paula; Pujo, Julien; Cenac, Nicolas; Bähr, Andrea; Klymiuk, Nikolai; Guillon, Antoine; Si-Tahar, Mustapha; Caballero, Ignacio
Abstract:
BACKGROUND: The hallmark of the cystic fibrosis (CF) lung disease is a neutrophil dominated lung environment that is associated to chronic lung tissue destruction and ultimately the patient's death. It is unclear whether the exacerbated neutrophil response is primary related to a defective CFTR or rather secondary to chronic bacterial colonization and inflammation. Here, we hypothesized that CF peripheral blood neutrophils present intrinsic alteration at birth before the start of an inflammatory...     »
Journal title abbreviation:
J Cyst Fibros
Year:
2020
Journal volume:
19
Journal issue:
5
Pages contribution:
830-836
Fulltext / DOI:
doi:10.1016/j.jcf.2020.02.016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32165155
Print-ISSN:
1569-1993
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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