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Title:

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Ear, Jason; Dunkel, Ying; Mittal, Yash; Lim, Blaze B C; Liu, Lawrence; Holda, Magda K; Nitsche, Ulrich; Barbazán, Jorge; Goel, Ajay; Janssen, Klaus-Peter; Aznar, Nicolas; Ghosh, Pradipta
Abstract:
Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplastic transformation and tumor growth, but later it triggers epithelial-to-mesenchymal-transition (EMT). We have identified and characterized two isoforms of the human Daple gene. While both isoforms coo...     »
Journal title abbreviation:
Sci Rep
Year:
2019
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-019-48420-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31431650
Print-ISSN:
2045-2322
TUM Institution:
Chirurgische Klinik und Poliklinik
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