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Titel:

The role of preoperative albumin-bilirubin grade for oncological risk stratification in liver transplant patients with hepatocellular carcinoma.

Dokumenttyp:
Article; Journal Article
Autor(en):
Kornberg, Arno; Witt, Ulrike; Schernhammer, Martina; Kornberg, Jennifer; Müller, Katharina; Friess, Helmut; Thrum, Katharina
Abstract:
BACKGROUND AND OBJECTIVES: Albumin-bilirubin (ALBI) score was shown to correlate with liver function and tumor recurrence after hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to assess the prognostic value of ALBI grade in liver transplantation (LT) patients with HCC. METHODS: Pre-LT available independent predictors of recurrence-free survival (RFS) and microvascular tumor invasion (MVI) were determined in 123 patients with HCC. RESULTS: Posttransplant HCC recurrence rates were 10.5%, 15.9%, and 68.2% in ALBI grade 1, 2, and 3, respectively (P < .001). Along with serum α-fetoprotein (AFP) and C-reactive protein (CRP) levels, ALBI grades 1 or 2 was identified as an independent predictor of RFS (hazard ratio, 3.52; 95% confidence interval [CI], 1.577-7.842; P = .002). Furthermore, ALBI grade 3 proved to be the strongest indicator of MVI (odds ratio, 11.59; 95% CI, 3.412-39.381; P < .001). A novel oncological risk score-based on AFP, CRP, and ALBI grade provided the best discriminative capacity (c-statistic 0.806) in selecting liver recipients with low oncological risk profile. CONCLUSION: Preoperative ALBI grade seems to be valuable for refinement of oncological risk stratification at LT for HCC.
Zeitschriftentitel:
J Surg Oncol
Jahr:
2019
Band / Volume:
120
Heft / Issue:
7
Seitenangaben Beitrag:
1126-1136
Volltext / DOI:
doi:10.1002/jso.25721
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31578753
Print-ISSN:
0022-4790
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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