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Title:

Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis.

Document type:
Comparative Study; Journal Article
Author(s):
Muller, I; Vaegler, M; Holzwarth, C; Tzaribatchev, N; Pfister, SM; Schütt, B; Reize, P; Greil, J; Handgretinger, R; Rudert, M
Abstract:
Osteonecrosis is a frequent complication after treatment for childhood leukemia and other steroid-based therapies. The success rate of core decompression surgery is limited. Therefore, we evaluated relevant biological characteristics of human multipotent mesenchymal stromal cells (MSCs) in vitro. MSCs cultured under low-oxygen tensions showed decreased proliferation and differentiation into bone. However, these MSCs secreted significant amounts of vascular endothelial-derived factor in the prese...     »
Journal title abbreviation:
Leukemia
Year:
2008
Journal volume:
22
Journal issue:
11
Pages contribution:
2054-61
Language:
eng
Fulltext / DOI:
doi:10.1038/leu.2008.217
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18719618
Print-ISSN:
0887-6924
TUM Institution:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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