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Title:

Assessing the causal association of glycine with risk of cardio-metabolic diseases.

Document type:
Article; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Author(s):
Wittemans, Laura B L; Lotta, Luca A; Oliver-Williams, Clare; Stewart, Isobel D; Surendran, Praveen; Karthikeyan, Savita; Day, Felix R; Koulman, Albert; Imamura, Fumiaki; Zeng, Lingyao; Erdmann, Jeanette; Schunkert, Heribert; Khaw, Kay-Tee; Griffin, Julian L; Forouhi, Nita G; Scott, Robert A; Wood, Angela M; Burgess, Stephen; Howson, Joanna M M; Danesh, John; Wareham, Nicholas J; Butterworth, Adam S; Langenberg, Claudia
Abstract:
Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role. We present a meta-analysis of genome-wide association studies for glycine in 80,003 participants and investigate the causality and potential mechanisms of the association between glycine and cardio-metabolic diseases using genetic approaches. We identify 27 genetic loci, of which 22 have not pr...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-019-08936-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30837465
Print-ISSN:
2041-1723
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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