Can the Injected Dose Be Reduced in 68Ga-PSMA-11 PET/CT While Maintaining High Image Quality for Lesion Detection?

Rauscher, Isabel; Fendler, Wolfgang P; Hope, Thomas A; Quon, Andrew; Nekolla, Stephan G; Calais, Jeremie; Richter, Antonia; Haller, Bernhard; Herrmann, Ken; Weber, Wolfgang A; Czernin, Johannes; Eiber, Matthias

doi:10.2967/jnumed.119.227207

2020

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Titel:: Can the Injected Dose Be Reduced in 68Ga-PSMA-11 PET/CT While Maintaining High Image Quality for Lesion Detection?
Dokumenttyp:: Journal Article
Autor(en):: Rauscher, Isabel; Fendler, Wolfgang P; Hope, Thomas A; Quon, Andrew; Nekolla, Stephan G; Calais, Jeremie; Richter, Antonia; Haller, Bernhard; Herrmann, Ken; Weber, Wolfgang A; Czernin, Johannes; Eiber, Matthias
Abstract:: Our purpose was to define a clinically useful lower limit of injected dose for 68Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT imaging of prostate cancer. Methods:68Ga-PSMA-11 PET/CT was performed on 11 patients. PET was acquired in list mode and reconstructed using a 3-min full acquisition, a 2-min acquisition, and a 1-min acquisition to generate images obtained with three thirds (standard dose), two thirds (low dose), and one third (very low dose) of the injected dose, respectively. Overall image quality (5-point scale) was assessed, and the detectability of PSMA-positive lesions was determined by 3 readers and compared with the reference standard. Results: Image quality declined with decreasing dose (mean score of 4.1 ± 0.4 for the standard dose, 3.4 ± 0.7 for the low dose, and 1.9 ± 0.4 for the very low dose; all P < 0.05). Readers 1, 2, and 3 correctly identified the lesions (n = 21) at a rate of 100%, 100%, and 95% with the standard dose; 95%, 81%, and 90% with the low dose; and 71%, 76%, and 59% with the very low dose, respectively. Conclusion:68Ga-PSMA-11 dose reduction is not feasible without a negative impact on image quality and lesion detectability.
Zeitschriftentitel:: J Nucl Med
Jahr:: 2020
Band / Volume:: 61
Heft / Issue:: 2
Seitenangaben Beitrag:: 189-193
Volltext / DOI:: doi:10.2967/jnumed.119.227207
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/31324710
Print-ISSN:: 0161-5505
TUM Einrichtung:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Nuklearmedizin
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