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Title:

CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma.

Document type:
Journal Article
Author(s):
Herhaus, Peter; Lipkova, Jana; Lammer, Felicitas; Yakushev, Igor; Vag, Tibor; Slotta-Huspenina, Julia; Habringer, Stefan; Lapa, Constantin; Pukrop, Tobias; Hellwig, Dirk; Wiestler, Benedikt; Buck, Andreas K; Deckert, Martina; Wester, Hans-Juergen; Bassermann, Florian; Schwaiger, Markus; Weber, Wolfgang Andreas; Menze, Bjoern; Keller, Ulrich
Abstract:
C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. MRI is the standard imaging technology for central nervous system (CNS) involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. Methods: In this proof-of-concept study, 11 patients with lymphoma of the CNS (8 primar...     »
Journal title abbreviation:
J Nucl Med
Year:
2020
Journal volume:
61
Journal issue:
12
Pages contribution:
1765-1771
Fulltext / DOI:
doi:10.2967/jnumed.120.241703
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32332145
Print-ISSN:
0161-5505
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin
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