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Title:

Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Author(s):
Dincer, Aylin; Gordon, Brian A; Hari-Raj, Amrita; Keefe, Sarah J; Flores, Shaney; McKay, Nicole S; Paulick, Angela M; Shady Lewis, Kristine E; Feldman, Rebecca L; Hornbeck, Russ C; Allegri, Ricardo; Ances, Beau M; Berman, Sarah B; Brickman, Adam M; Brooks, William S; Cash, David M; Chhatwal, Jasmeer P; Farlow, Martin R; la Fougère, Christian; Fox, Nick C; Fulham, Michael J; Jack, Clifford R; Joseph-Mathurin, Nelly; Karch, Celeste M; Lee, Athene; Levin, Johannes; Masters, Colin L; McDade, Eric M;...     »
Abstract:
Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since late-onset Alzheimer disease (LOAD) participants tend to have age-related comorbidities, the younger-onset age in autosomal dominant AD (ADAD) may provide a more idealized model of cortical thinning in AD. To test this, the goals of this study were to compare the degree of ov...     »
Journal title abbreviation:
Neuroimage Clin
Year:
2020
Journal volume:
28
Fulltext / DOI:
doi:10.1016/j.nicl.2020.102491
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33395982
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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