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Title:

18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases.

Document type:
Journal Article; Article
Author(s):
Grimmer, Timo; Shi, Kuangyu; Diehl-Schmid, Janine; Natale, Bianca; Drzezga, Alexander; Forster, Stefan; Förstl, Hans; Schwaiger, Markus; Yakushev, Igor; Wester, Hans-Jürgen; Kurz, Alexander; Yousefi, Behrooz Hooshyar
Abstract:
18F-FIBT, 2-(p-Methylaminophenyl)-7-(2-[18F]fluoroethoxy)imidazo-[2,1-b]benzothiazole, is a new selective PET tracer under clinical investigation to specifically image β-amyloid depositions (Aβ) in humans in-vivo that binds to Aβ with excellent affinity (Kd 0.7 ± 0.2) and high selectivity over tau and α-synuclein aggregates (Ki > 1000 nM). We aimed to characterize 18F-FIBT in a series of patients with different clinical-pathophysiological phenotypes and to compare its binding characteristics to...     »
Journal title abbreviation:
Mol Psychiatry
Year:
2020
Journal volume:
25
Journal issue:
10
Pages contribution:
2608-2619
Language:
eng
Fulltext / DOI:
doi:10.1038/s41380-018-0203-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30120417
Print-ISSN:
1359-4184
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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