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Title:

Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia.

Document type:
Journal Article
Author(s):
Avram, Mihai; Brandl, Felix; Knolle, Franziska; Cabello, Jorge; Leucht, Claudia; Scherr, Martin; Mustafa, Mona; Koutsouleris, Nikolaos; Leucht, Stefan; Ziegler, Sibylle; Sorg, Christian
Abstract:
Aberrant dopamine function in the dorsal striatum and aberrant intrinsic functional connectivity (iFC) between distinct cortical networks and thalamic nuclei are among the most consistent large-scale brain imaging findings in schizophrenia. A pathophysiological link between these two alterations is suggested by theoretical models based on striatal dopamine's topographic modulation of cortico-thalamic connectivity within cortico-basal-ganglia-thalamic circuits. We hypothesized that aberrant stria...     »
Journal title abbreviation:
Brain
Year:
2020
Journal volume:
143
Journal issue:
11
Pages contribution:
3495-3505
Fulltext / DOI:
doi:10.1093/brain/awaa296
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33155047
Print-ISSN:
0006-8950
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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