Login
mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2020
- Dokumenttyp:
- Article; Journal Article
- Autor(en):
- Scharl, Sophia; Kessel, Kerstin A; Diehl, Christian; Gempt, Jens; Meyer, Bernhard; Zimmer, Claus; Straube, Christoph; Combs, Stephanie E
- Titel:
- Is local radiotherapy a viable option for patients with an opening of the ventricles during surgical resection of brain metastases?
- Abstract:
- BACKGROUND: Local hypofractionated stereotactic radiotherapy (HFSRT) of the resection cavity is emerging as the standard of care in the treatment of patients with a limited number of brain metastases as it warrants less neurological impairment compared to whole brain radiotherapy. In periventricular metastases surgical resection can lead to an opening of the ventricles and subsequently carries a potential risk of cerebrospinal tumour cell dissemination. The aim of this study was to assess whether local radiotherapy of the resection cavity is viable in these cases. METHODS: From our institutional database we analyzed the data of 125 consecutive patients with resected brain metastases treated in our institution with HFSRT between 2009 and 2017. The incidence of LMD, overall survival (OS), local recurrence (LC) and distant recurrence were evaluated depending on ventricular opening (VO) during surgery. RESULTS: From all 125 patients, the ventricles were opened during surgery in 14 cases (11.2%). None of the patients with VO and 7 patients without VO during surgery developed LMD (p = 0.371). OS (p = 0.817), LC (p = 0.524) and distant recurrence (p = 0.488) did not differ in relation to VO during surgical resection. However, the incidence of distant intraventricular recurrence was slightly increased in patients with VO (14.3% vs. 2.7%, p < 0.01). CONCLUSION: VO during neurosurgical resection did not affect the outcome after HFSRT of the resection cavity in patients with brain metastases. Particularly, the incidence of LMD was not increased in patients receiving local HFSRT after VO. HFSRT can therefore be offered independently of VO as a local treatment of tumor bed after resection of brain metastases.
- Zeitschriftentitel:
- Radiat Oncol
- Jahr:
- 2020
- Band / Volume:
- 15
- Heft / Issue:
- 1
- Volltext / DOI:
- doi:10.1186/s13014-020-01725-x
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/33303000
- Print-ISSN:
- 1748-717X
- TUM Einrichtung:
- Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Neurochirurgische Klinik und Poliklinik
BibTeX
Vorkommen:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurochirurgie (Prof. Meyer)2020
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2020