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Titel:

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Montagnese, Marcella; Knolle, Franziska; Haarsma, Joost; Griffin, Juliet D; Richards, Alex; Vertes, Petra E; Kiddle, Beatrix; Fletcher, Paul C; Jones, Peter B; Owen, Michael J; Fonagy, Peter; Bullmore, Edward T; Dolan, Raymond J; Moutoussis, Michael; Goodyer, Ian M; Murray, Graham K
Abstract:
BACKGROUND: Schizophrenia is a complex disorder in which the causal relations between risk genes and observed clinical symptoms are not well understood and the explanatory gap is too wide to be clarified without considering an intermediary level. Thus, we aimed to test the hypothesis of a pathway from molecular polygenic influence to clinical presentation occurring via deficits in reinforcement learning. METHODS: We administered a reinforcement learning task (Go/NoGo) that measures reinforcement...     »
Zeitschriftentitel:
Schizophr Res
Jahr:
2020
Band / Volume:
222
Seitenangaben Beitrag:
389-396
Volltext / DOI:
doi:10.1016/j.schres.2020.04.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32389614
Print-ISSN:
0920-9964
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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