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Title:

Intrathecal nusinersen administration in adult spinal muscular atrophy patients with complex spinal anatomy.

Document type:
Article; Journal Article
Author(s):
Cordts, Isabell; Lingor, Paul; Friedrich, Benjamin; Pernpeintner, Verena; Zimmer, Claus; Deschauer, Marcus; Maegerlein, Christian
Abstract:
Background: Intrathecal administration of nusinersen in adult spinal muscular atrophy (SMA) patients presents challenges owing to severe scoliosis and previous spinal surgery with metal implantation. In patients with a complex spinal situation, the potential risks of the intrathecal administration may lead to delayed treatment initiation. Methods: In this study, we analyzed 53 CT-guided lumbar punctures of 11 adult nonambulatory SMA type 2 and 3 patients. All patients had scoliosis and six patie...     »
Journal title abbreviation:
Therap Adv Neurol Dis
Year:
2020
Journal volume:
13
Fulltext / DOI:
doi:10.1177/1756286419887616
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32010224
Print-ISSN:
1756-2856
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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