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Title:

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Sul, Jae Hoon; Service, Susan K; Huang, Alden Y; Ramensky, Vasily; Hwang, Sun-Goo; Teshiba, Terri M; Park, YoungJun; Ori, Anil P S; Zhang, Zhongyang; Mullins, Niamh; Olde Loohuis, Loes M; Fears, Scott C; Araya, Carmen; Araya, Xinia; Spesny, Mitzi; Bejarano, Julio; Ramirez, Margarita; Castrillón, Gabriel; Gomez-Makhinson, Juliana; Lopez, Maria C; Montoya, Gabriel; Montoya, Claudia P; Aldana, Ileana; Escobar, Javier I; Ospina-Duque, Jorge; Kremeyer, Barbara; Bedoya, Gabriel; Ruiz-Linares, Andres;...     »
Abstract:
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP) in numerous multigenerational pedigrees suggests that, in such families, large-effect inherited variants might play a greater role. To identify roles of rare and common variants on BP, we conducted genetic analyses in 26 Colombia and Costa Rica...     »
Journal title abbreviation:
Transl Psychiatry
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41398-020-0758-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32094344
Print-ISSN:
2158-3188
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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