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Title:

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Aguilar-Pimentel, Juan Antonio; Cho, Yi-Li; Gerlini, Raffaele; Calzada-Wack, Julia; Wimmer, Maria; Mayer-Kuckuk, Philipp; Adler, Thure; Schmidt-Weber, Carsten B; Busch, Dirk H; Fuchs, Helmut; Gailus-Durner, Valérie; Ollert, Markus; Hrabě de Angelis, Martin; Ohlsson, Claes; Poutanen, Matti; Teperino, Raffaele; Strauss, Leena
Abstract:
Sex steroids, such as estrogens and androgens, are important regulators of the humoral immune response. Studies in female mice have demonstrated that alteration of circulating estrogen concentration regulates antibody-mediated immunity. As males have normally little endogenous estrogen, we hypothesized that in males high estrogens and low androgens affect the immune system and enhance the allergic inflammatory response. Here, we studied transgenic male mice expressing human aromatase (AROM+). Th...     »
Journal title abbreviation:
Sci Rep
Year:
2020
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-020-75059-9
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33110090
Print-ISSN:
2045-2322
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Molekulare Allergologie (Prof. Schmidt-Weber)
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