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Title:

A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Rechenmacher, Florian; Neubauer, Stefanie; Mas-Moruno, Carlos; Dorfner, Petra M; Polleux, Julien; Guasch, Judith; Conings, Bert; Boyen, Hans-Gerd; Bochen, Alexander; Sobahi, Tariq R; Burgkart, Rainer; Spatz, Joachim P; Fässler, Reinhard; Kessler, Horst
Abstract:
We present a click chemistry-based molecular toolkit for the biofunctionalization of materials to selectively control integrin-mediated cell adhesion. To this end, ?5?1-selective RGD peptidomimetics were covalently immobilized on Ti-based materials, and the capacity to promote the selective binding of ?5?1 was evaluated using a solid-phase integrin binding assay. This functionalization strategy yielded surfaces with a nine-fold increased affinity for ?5?1, in comparison to control samples, and t...     »
Journal title abbreviation:
Chemistry
Year:
2013
Journal volume:
19
Journal issue:
28
Pages contribution:
9218-23
Language:
eng
Fulltext / DOI:
doi:10.1002/chem.201301478
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23744802
Print-ISSN:
0947-6539
TUM Institution:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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