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Dokumenttyp:
Journal Article
Autor(en):
Khajavi, Noushafarin; Finan, Brian; Kluth, Oliver; Müller, Timo D; Mergler, Stefan; Schulz, Angela; Kleinau, Gunnar; Scheerer, Patrick; Schürmann, Annette; Gudermann, Thomas; Tschöp, Matthias H; Krude, Heiko; DiMarchi, Richard D; Biebermann, Heike
Titel:
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.
Abstract:
Recently, a unimolecular tri-agonist with activity at glucagon-like peptide 1 receptor (GLP-1R), glucose dependent insulinotropic receptor, and the glucagon receptor was reported to improve glycemic control in mice. Here, we defined the underlying molecular mechanisms of enhanced insulin secretion in murine pancreatic islets for a specific tri-agonist. The tri-agonist induced an increase in insulin secretion from murine islets compared to the respective mono-agonists. GLP-1R mainly signals via a...     »
Zeitschriftentitel:
Cell Signal
Jahr:
2018
Band / Volume:
51
Seitenangaben Beitrag:
13-22
Volltext / DOI:
doi:10.1016/j.cellsig.2018.07.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30055232
Print-ISSN:
0898-6568
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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