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Titel:

Circulating HDL levels control hypothalamic astrogliosis via apoA-I.

Dokumenttyp:
Journal Article; Article
Autor(en):
Götz, Anna; Lehti, Maarit; Donelan, Elizabeth; Striese, Cynthia; Cucuruz, Sebastian; Sachs, Stephan; Yi, Chun-Xia; Woods, Stephen C; Wright, Samuel D; Müller, Timo D; Tschöp, Matthias H; Gao, Yuanqing; Hofmann, Susanna M
Abstract:
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced neuronal injury triggers microgliosis and astrocytosis, conditions which ultimately may induce functional impairment of hypothalamic circuits governing feeding behavior, systemic metabolism, and body weight. Epidemiological data indicate that low circ...     »
Zeitschriftentitel:
J Lipid Res
Jahr:
2018
Band / Volume:
59
Heft / Issue:
9
Seitenangaben Beitrag:
1649-1659
Volltext / DOI:
doi:10.1194/jlr.M085456
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29991652
Print-ISSN:
0022-2275
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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