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Title:

Gut hormone polyagonists for the treatment of type 2 diabetes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Brandt, Sara J; Götz, Anna; Tschöp, Matthias H; Müller, Timo D
Abstract:
Chemical derivatives of the gut-derived peptide hormone glucagon-like peptide 1 (GLP-1) are among the best-in-class pharmacotherapies to treat obesity and type 2 diabetes. However, GLP-1 analogs have modest weight lowering capacity, in the range of 5-10%, and the therapeutic window is hampered by dose-dependent side effects. Over the last few years, a new concept has emerged: combining the beneficial effects of several key metabolic hormones into a single molecular entity. Several unimolecular G...     »
Journal title abbreviation:
Peptides
Year:
2018
Journal volume:
100
Pages contribution:
190-201
Fulltext / DOI:
doi:10.1016/j.peptides.2017.12.021
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29412819
Print-ISSN:
0196-9781
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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