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Title:

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Author(s):
Huang, Jianfeng; Duran, Angeles; Reina-Campos, Miguel; Valencia, Tania; Castilla, Elias A; Müller, Timo D; Tschöp, Matthias H; Moscat, Jorge; Diaz-Meco, Maria T
Abstract:
Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adipocytes. p62 loss in adipocytes results in increased osteopontin secretion, which mediates tumor fatty acid oxidation and invasion, leading to aggressive metastatic PCa in vivo. Fur...     »
Journal title abbreviation:
Cancer Cell
Year:
2018
Journal volume:
33
Journal issue:
4
Pages contribution:
770-784.e6
Fulltext / DOI:
doi:10.1016/j.ccell.2018.03.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29634950
Print-ISSN:
1535-6108
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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