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Title:

[Exercise Training in Patients with Pulmonary Hypertension: A Systematic Review and Meta-analysis].

Document type:
Review; Journal Article; Meta-Analysis; Systematic Review
Author(s):
Glöckl, R; Schneeberger, T; Boeselt, T; Kenn, K; Koczulla, A R; Held, M; Oberhoffer, R; Halle, M
Abstract:
BACKGROUND:  Pulmonary hypertension (PH) is defined as an elevation of mean pulmonary-arterial pressure by > 20 mmHg at rest, which may lead to right heart failure. Physical exercise has not been regularly recommended for PH patients for fear of symptom deterioration or occurrence of exercise-induced adverse events. METHODS:  Three electronic databases were searched for randomized, controlled trials investigating exercise training in PH patients using the following keywords: "pulmonary hypertension" OR "pulmonary arterial hypertension" AND "exercise" OR "pulmonary rehabilitation" AND "randomized". RESULTS:  Five studies involving 187 PH patients were included in this systematic review. Exercise programs lasted for 3 - 12 weeks (e. g. endurance training for 10 - 45 minutes; 60 - 80 % of the peak heart rate). PH patients significantly improved exercise capacity compared to controls in 6-minute walk distance (+ 45 m; 95 % CI: 26 m - 64 m) or peak oxygen consumption (+ 2.3 ml/kg/min; 95 % CI: 1.8 - 2.9 ml/kg/min), both p < 0.001. Also, physical and mental quality of life improved significantly by exercise training. No exercise-induced adverse events were observed. CONCLUSION:  Supervised exercise training can safely and significantly improve physical performance and quality of life in clinically stable PH patients with optimal drug treatment. However, larger studies including a wider range of PH are mandatory.
Journal title abbreviation:
Pneumologie
Year:
2019
Journal volume:
73
Journal issue:
11
Pages contribution:
677-685
Fulltext / DOI:
doi:10.1055/a-1005-8678
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31715636
Print-ISSN:
0934-8387
TUM Institution:
Poliklinik für Präventive und Rehabilitative Sportmedizin
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