Correlation of the quantitative level of MGMT promoter methylation and overall survival in primary diagnosed glioblastomas using the quantitative MethyQESD method.

Titel:: Correlation of the quantitative level of MGMT promoter methylation and overall survival in primary diagnosed glioblastomas using the quantitative MethyQESD method.
Dokumenttyp:: Journal Article
Autor(en):: von Rosenstiel, Charlotte; Wiestler, Benedikt; Haller, Bernhard; Schmidt-Graf, Friederike; Gempt, Jens; Bettstetter, Marcus; Rihani, Laura; Wu, Wei; Meyer, Bernhard; Schlegel, Jürgen; Liesche-Starnecker, Friederike
Abstract:: AIMS: O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation is a high predictive factor for therapy results of temozolomide in patients with glioma. The objective of this work was to analyse the impact of MGMT promoter methylation in patients with primary diagnosed glioblastoma (GBM) relating to survival using a quantitative method (methylation quantification of endonuclease-resistant DNA, MethyQESD) by verifying a cut-off point for MGMT methylation provided by the literature (
Zeitschriftentitel:: J Clin Pathol
Jahr:: 2020
Band / Volume:: 73
Heft / Issue:: 2
Seitenangaben Beitrag:: 112-115
Volltext / DOI:: doi:10.1136/jclinpath-2019-206104
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/31422371
Print-ISSN:: 0021-9746
TUM Einrichtung:: Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Neurochirurgische Klinik und Poliklinik; Neurologische Klinik und Poliklinik
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