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- Titel:
Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Sales, Arthur H A; Bette, Stefanie; Barz, Melanie; Huber, Thomas; Wiestler, Benedikt; Ryang, Yu-Mi; Schmidt-Graf, Friederike; Liesche, Friederike; Combs, Stephanie E; Meyer, Bernhard; Gempt, Jens
- Abstract:
- PURPOSE: The aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients. METHODS: One hundred-twenty-six patients with MGMT-unmethylated glioblastoma who were treated either with surgical resection or needle biopsy between 2006 and 2015 were included in this retrospective cohort. Pre- and postcontrast T1 weighted images were evaluated in order to determine pre- and postoperative contrast-enhancing tumor volumes (CE-TV). Cox regression models adjusted for other significant prognostic factors were used to investigate the association between postoperative tumor volume and survival. RESULTS: Complete resection of CE-TV was significantly associated with longer OS in the univariate analysis (HR 0.61; 95% CI 0.40-0.94; p = 0.02). However, this fact could not be confirmed after adjusting the model for other relevant prognostic factors (HR 1.01; 95% CI 0.65-1.55; p = 0.962). Postoperative CE-TV was significantly associated with survival in both univariate (HR: 1.04; 95% CI 1.025-1.055; p < 0.001) and multivariate analyses (HR: 1.027; 95% CI 1.005-1.049; p = 0.014). CONCLUSIONS: Although complete resection of tumor tissue was not significantly associated with longer OS in MGMT-unmethylated GBM patients, maximum safe resection should always be attempted, since postoperative tumor volume is strongly associated with OS.
- Zeitschriftentitel:
- J Neurooncol
- Jahr:
- 2019
- Band / Volume:
- 142
- Heft / Issue:
- 3
- Seitenangaben Beitrag:
- 529-536
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1007/s11060-019-03124-z
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/30790133
- Print-ISSN:
- 0167-594X
- TUM Einrichtung:
- Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Neurochirurgische Klinik und Poliklinik; Neurologische Klinik und Poliklinik
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Vorkommen:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2019
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)Professur für Neuroradiologie (Prof. Zimmer)2019
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurologie (Prof. Hemmer)2019
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineKlinik und Poliklinik für Neurochirurgie (Prof. Meyer)2019