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Titel:

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil.

Dokumenttyp:
Journal Article
Autor(en):
Ortner, Marion; Stange, Marion; Schneider, Heike; Schröder, Charlotte; Buerger, Katharina; Müller, Claudia; Müller-Sarnowski, Felix; Diehl-Schmid, Janine; Förstl, Hans; Grimmer, Timo; Steimer, Werner
Abstract:
Background: The efficacy of acetylcholinesterase inhibitors (AChE-I) might depend on blood concentration. While rivastigmine metabolism is independent of the cytochrome P450 system, its isoenzymes, especially CYP2D6, metabolize donepezil. CYP2D6 polymorphisms can cause altered enzyme activity resulting in lower or higher than expected drug concentrations of donepezil. Objective: We investigated correlations between clinical efficacy and serum concentrations of rivastigmine and donepezil under sp...     »
Zeitschriftentitel:
Drug Des Devel Ther
Jahr:
2020
Band / Volume:
14
Seitenangaben Beitrag:
3251-3262
Volltext / DOI:
doi:10.2147/DDDT.S247259
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32848364
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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