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- Title:
A diagnostic algorithm for detection of urinary tract infections in hospitalized patients with bacteriuria: The "Triple F" approach supported by Procalcitonin and paired blood and urine cultures.
- Document type:
- Article; Journal Article
- Author(s):
- Rothe, Kathrin; Spinner, Christoph D; Waschulzik, Birgit; Janke, Christian; Schneider, Jochen; Schneider, Heike; Braitsch, Krischan; Smith, Christopher; Schmid, Roland M; Busch, Dirk H; Katchanov, Juri
- Abstract:
- For acute medicine physicians, distinguishing between asymptomatic bacteriuria (ABU) and clinically relevant urinary tract infections (UTI) is challenging, resulting in overtreatment of ABU and under-recognition of urinary-source bacteraemia without genitourinary symptoms (USB). We conducted a retrospective analysis of ED encounters in a university hospital between October 2013 and September 2018 who met the following inclusion criteria: Suspected UTI with simultaneous collection of paired urinary cultures and blood cultures (PUB) and determination of Procalcitonin (PCT). We sought to develop a simple algorithm based on clinical signs and PCT for the management of suspected UTI. Individual patient presentations were retrospectively evaluated by a clinical "triple F" algorithm (F1 ="fever", F2 ="failure", F3 ="focus") supported by PCT and PUB. We identified 183 ED patients meeting the inclusion criteria. We introduced the term UTI with systemic involvement (SUTI) with three degrees of diagnostic certainty: bacteremic UTI (24.0%; 44/183), probable SUTI (14.2%; 26/183) and possible SUTI (27.9%; 51/183). In bacteremic UTI, half of patients (54.5%; 24/44) presented without genitourinary symptoms. Discordant bacteraemia was diagnosed in 16 patients (24.6% of all bacteremic patients). An alternative focus was identified in 67 patients, five patients presented with S. aureus bacteremia. 62 patients were diagnosed with possible UTI (n = 20) or ABU (n = 42). Using the proposed "triple F" algorithm, dichotomised PCT of < 0.25 pg/ml had a negative predictive value of 88.7% and 96.2% for bacteraemia und accordant bacteraemia respectively. The application of the algorithm to our cohort could have resulted in 33.3% reduction of BCs. Using the diagnostic categories "possible" or "probable" SUTI as a trigger for initiation of antimicrobial treatment would have reduced or streamlined antimicrobial use in 30.6% and 58.5% of cases, respectively. In conclusion, the "3F" algorithm supported by PCT and PUB is a promising diagnostic and antimicrobial stewardship tool.
- Journal title abbreviation:
- PLoS ONE
- Year:
- 2020
- Journal volume:
- 15
- Journal issue:
- 10
- Fulltext / DOI:
- doi:10.1371/journal.pone.0240981
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/33091046
- Print-ISSN:
- 1932-6203
- TUM Institution:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Medizinische Statistik und Epidemiologie
BibTeX
Occurrences:
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsPreclinical MedicineInstitut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch)2020
- mediaTUM GesamtbestandHochschulbibliographie2020FakultätenMedizinInstitut für Klinische Chemie und Pathobiochemie
- mediaTUM GesamtbestandHochschulbibliographie2020FakultätenMedizinInstitut für Medizinische Statistik und Epidemiologie
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für KI und Informatik in der Medizin (Prof. Rückert)2020
- mediaTUM GesamtbestandEinrichtungenSchools TUM School of Medicine and HealthDepartmentsClinical MedicineInstitut für Klinische Chemie und Pathobiochemie (Prof. Ruland)2020