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Titel:

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Varga, Julia; Nicolas, Adele; Petrocelli, Valentina; Pesic, Marina; Mahmoud, Abdelrahman; Michels, Birgitta E; Etlioglu, Emre; Yepes, Diego; Häupl, Björn; Ziegler, Paul K; Bankov, Katrin; Wild, Peter J; Wanninger, Stefan; Medyouf, Hind; Farin, Henner F; Tejpar, Sabine; Oellerich, Thomas; Ruland, Jürgen; Siebel, Christian W; Greten, Florian R
Abstract:
Recently, a transcriptome-based consensus molecular subtype (CMS) classification of colorectal cancer (CRC) has been established, which may ultimately help to individualize CRC therapy. However, the lack of animal models that faithfully recapitulate the different molecular subtypes impedes adequate preclinical testing of stratified therapeutic concepts. Here, we demonstrate that constitutive AKT activation in intestinal epithelial cells markedly enhances tumor invasion and metastasis in Trp53ΔIE...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2020
Band / Volume:
217
Heft / Issue:
10
Volltext / DOI:
doi:10.1084/jem.20191515
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32749453
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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