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Titel:

Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer's Dementia Are Frequently Below the Recommended Levels.

Dokumenttyp:
Journal Article
Autor(en):
Ortner, Marion; Stange, Marion; Schneider, Heike; Schroeder, Charlotte; Buerger, Katharina; Müller, Claudia; Dorn, Bianca; Goldhardt, Oliver; Diehl-Schmid, Janine; Förstl, Hans; Steimer, Werner; Grimmer, Timo
Abstract:
Background: Acetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia. They are widely used not only in Alzheimer's disease, but also in other forms of dementia. Efficacy of treatment might depend on serum concentration of the respective AChE-I. Objective: In patients with mild to moderate Alzheimer's dementia, we measured serum concentrations of hepatically metabolized donepezil and renally excr...     »
Zeitschriftentitel:
Front Pharmacol
Jahr:
2020
Band / Volume:
11
Volltext / DOI:
doi:10.3389/fphar.2020.00691
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32508640
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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