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Titel:

The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Brueffer, Christian; Gladchuk, Sergii; Winter, Christof; Vallon-Christersson, Johan; Hegardt, Cecilia; Häkkinen, Jari; George, Anthony M; Chen, Yilun; Ehinger, Anna; Larsson, Christer; Loman, Niklas; Malmberg, Martin; Rydén, Lisa; Borg, Åke; Saal, Lao H
Abstract:
Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN-B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA-seq pipeline for detection of SNVs/indels and profiled a real-world cohort of 3,217 breast tumors. We describe the mutational landscape of primary breast cancer vi...     »
Zeitschriftentitel:
EMBO Mol Med
Jahr:
2020
Band / Volume:
12
Heft / Issue:
10
Volltext / DOI:
doi:10.15252/emmm.202012118
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32926574
Print-ISSN:
1757-4676
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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