Bicuspid Aortic Valve Anatomy and Relationship With Devices: The BAVARD Multicenter Registry.

Tchetche, Didier; De Biase, Chiara; van Gils, Lennart; Parma, Radoslaw; Ochala, Andrzej; Lefèvre, Thierry; Hovasse, Thomas; De Backer, Ole; Sondergaard, Lars; Bleiziffer, Sabine; Lange, Rüdiger; Kornowski, Ran; Landes, Uri; Norgaard, Bjarne Linde; Biasco, Luigi; Philippart, Raphael; Molina-Martin de Nicolas, Javier; Mylotte, Darren; Lemee, Caroline; Dumonteil, Nicolas; Van Mieghem, Nicolas M

doi:10.1161/CIRCINTERVENTIONS.118.007107

2019

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Document type:: Journal Article
Author(s):: Tchetche, Didier; De Biase, Chiara; van Gils, Lennart; Parma, Radoslaw; Ochala, Andrzej; Lefèvre, Thierry; Hovasse, Thomas; De Backer, Ole; Sondergaard, Lars; Bleiziffer, Sabine; Lange, Rüdiger; Kornowski, Ran; Landes, Uri; Norgaard, Bjarne Linde; Biasco, Luigi; Philippart, Raphael; Molina-Martin de Nicolas, Javier; Mylotte, Darren; Lemee, Caroline; Dumonteil, Nicolas; Van Mieghem, Nicolas M
Title:: Bicuspid Aortic Valve Anatomy and Relationship With Devices: The BAVARD Multicenter Registry.
Abstract:: BACKGROUND: Sizing for transcatheter aortic valve implantation in bicuspid aortic valves (BAV) remains controversial. METHODS AND RESULTS: The aim of the BAVARD (Bicuspid Aortic Valve Anatomy and Relationship With Devices) retrospective registry is to capture the sizing ratios used for transcatheter aortic valve implantation in BAV and analyze the second-generation prostheses geometry postimplantation. About 101 patients with BAV along with available pre- and post-transcatheter aortic valve implantation multidetector computed tomography were compared with 88 tricuspid aortic valves (TAV) patients. Preprocedural multidetector computed tomography diagnosed type 0 and type 1 BAV in, respectively, 12.9% and 86.1 % of BAV. At baseline, the ellipticity index was similar between BAV and TAV patients: 1.2±0.1 versus 1.2±0.1, P=0.09. The mean annular oversizing was, respectively, 1.14±0.04 and 1.04±0.04, P<0.001, in TAV and BAV patients. The mean prosthesis intercommissural distance, ratio was 1.03±0.1. The mean diameter of the prostheses at the annulus matched the mean perimeter-derived diameter of the aortic annulus at baseline with TAV (23.3±2.2 versus 23.6±1.9, P=0.4) and was smaller with BAV (24±2.8 versus 26.8±3.1, P<0.01), confirming 11% underexpansion in BAV. Finally, in situ, prosthesis diameter and ellipticity followed the same pattern, with stable values from the distal edge to 12 mm above, in both groups. CONCLUSIONS: Second-generation prostheses similarly reshape the aortic annulus in TAV and BAV. Prostheses keep consistent diameters from distal edge to 12 mm in TAV and BAV. Prosthesis underexpansion is constantly observed in BAV. Annular-based sizing is accurate in BAV with minimal oversizing. The intercommissural distance, 4 mm above the annulus, could be integrated in gray zones. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT03495050.
Journal title abbreviation:: Circ Cardiovasc Interv
Year:: 2019
Journal volume:: 12
Journal issue:: 1
Fulltext / DOI:: doi:10.1161/CIRCINTERVENTIONS.118.007107
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30626202
Print-ISSN:: 1941-7640
TUM Institution:: Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Gefäßchirurgie (DHM) (Prof. Krane)2019