Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.

Dokumenttyp:
Article
Autor(en):
Barbagiovanni, Giulia; Germain, Pierre-Luc; Zech, Michael; Atashpaz, Sina; Lo Riso, Pietro; D'Antonio-Chronowska, Agnieszka; Tenderini, Erika; Caiazzo, Massimiliano; Boesch, Sylvia; Jech, Robert; Haslinger, Bernhard; Broccoli, Vania; Stewart, Adrian Francis; Winkelmann, Juliane; Testa, Giuseppe
Abstract:
Transdifferentiation of fibroblasts into induced neuronal cells (iNs) by the neuron-specific transcription factors Brn2, Myt1l, and Ascl1 is a paradigmatic example of inter-lineage conversion across epigenetically distant cells. Despite tremendous progress regarding the transcriptional hierarchy underlying transdifferentiation, the enablers of the concomitant epigenome resetting remain to be elucidated. Here, we investigated the role of KMT2A and KMT2B, two histone H3 lysine 4 methylases with ca...     »
Zeitschriftentitel:
Cell Rep
Jahr:
2018
Band / Volume:
25
Heft / Issue:
4
Seitenangaben Beitrag:
988-1001
Volltext / DOI:
doi:10.1016/j.celrep.2018.09.067
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30355503
Print-ISSN:
2211-1247
TUM Einrichtung:
Institut für Humangenetik; Lehrstuhl für Neurogenetik (Prof. Winkelmann); Neurologische Klinik und Poliklinik
 BibTeX