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Titel:

OCR-Stats: Robust estimation and statistical testing of mitochondrial respiration activities using Seahorse XF Analyzer.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Yépez, Vicente A; Kremer, Laura S; Iuso, Arcangela; Gusic, Mirjana; Kopajtich, Robert; Koňařiková, Eliška; Nadel, Agnieszka; Wachutka, Leonhard; Prokisch, Holger; Gagneur, Julien
Abstract:
The accurate quantification of cellular and mitochondrial bioenergetic activity is of great interest in medicine and biology. Mitochondrial stress tests performed with Seahorse Bioscience XF Analyzers allow the estimation of different bioenergetic measures by monitoring the oxygen consumption rates (OCR) of living cells in multi-well plates. However, studies of the statistical best practices for determining aggregated OCR measurements and comparisons have been lacking. Therefore, to understand h...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2018
Band / Volume:
13
Heft / Issue:
7
Volltext / DOI:
doi:10.1371/journal.pone.0199938
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29995917
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Humangenetik
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