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Titel:

Antibodies conjugated with viral antigens elicit a cytotoxic T cell response against primary CLL ex vivo.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schneidt, Viktor; Ilecka, Marta; Dreger, Peter; van Zyl, Dwain G; Fink, Susanne; Mautner, Josef; Delecluse, Henri-Jacques
Abstract:
Chronic lymphocytic leukemia (CLL) is the most frequent B cell malignancy in Caucasian adults. The therapeutic armamentarium against this incurable disease has recently seen a tremendous expansion with the introduction of specific pathway inhibitors and innovative immunotherapy. However, none of these approaches is curative and devoid of side effects. We have used B-cell-specific antibodies conjugated with antigens (AgAbs) of the Epstein-Barr virus (EBV) to efficiently expand memory CD4+ cytotox...     »
Zeitschriftentitel:
Leukemia
Jahr:
2019
Band / Volume:
33
Heft / Issue:
1
Seitenangaben Beitrag:
88-98
Volltext / DOI:
doi:10.1038/s41375-018-0160-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29925906
Print-ISSN:
0887-6924
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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