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Titel:

Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice.

Dokumenttyp:
Journal Article
Autor(en):
Salminen, Aaro V; Lam, Daniel D; Winkelmann, Juliane
Abstract:
MEIS1 is a transcription factor playing an important role in the development of several organs, including central and peripheral nervous systems. A genetic locus spanning the MEIS1 coding region has been associated with the risk of RLS in genome-wide association studies, with increasing evidence that MEIS1 is the causal RLS gene. The RLS-linked genetic signal has been mapped to an intronic regulatory element within MEIS1. This element plays a role in the ganglionic eminences of the developing fo...     »
Zeitschriftentitel:
Adv Pharmacol
Jahr:
2019
Band / Volume:
84
Seitenangaben Beitrag:
175-184
Volltext / DOI:
doi:10.1016/bs.apha.2019.03.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31229170
Print-ISSN:
1054-3589
TUM Einrichtung:
Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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