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Title:

Novel fatty acid gentamicin salts as slow-release drug carrier systems for anti-infective protection of vascular biomaterials.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Obermeier, A; Matl, FD; Schwabe, J; Zimmermann, A; Kühn, KD; Lakemeier, S; von Eisenhart-Rothe, R; Stemberger, A; Burgkart, R
Abstract:
Infections of vascular prostheses are still a major risk in surgery. The current work presents an in vitro evaluation of novel slow release antibiotic coatings based on new gentamicin fatty acid salts for polytetrafluoroethylene grafts. These grafts were coated with gentamicin sodium dodecyl sulfate, gentamicin laurate and gentamicin palmitate. Drug release kinetics, anti-infective characteristics, biocompatibility and haemocompatibility of developed coatings were compared to commercially availa...     »
Journal title abbreviation:
J Mater Sci Mater Med
Year:
2012
Journal volume:
23
Journal issue:
7
Pages contribution:
1675-83
Language:
eng
Fulltext / DOI:
doi:10.1007/s10856-012-4631-5
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22476651
Print-ISSN:
0957-4530
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein); Klinik und Poliklinik für Orthopädie und Sportorthopädie
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