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Title:

Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur.

Document type:
Article; Journal Article
Author(s):
Hettwer, Werner; Horstmann, Peter F; Bischoff, Sabine; Güllmar, Daniel; Reichenbach, Jürgen R; Poh, Patrina S P; Van Griensven, Martijn; Gras, Florian; Diefenbeck, Michael
Abstract:
Assessment of bone graft material efficacy is difficult in humans, since invasive methods like staged CT scans or biopsies are ethically unjustifiable. Therefore, we developed a novel large animal model for the verification of a potential transformation of synthetic bone graft substitutes into vital bone. The model combines multiple imaging methods with corresponding histology in standardized critical sized cancellous bone defect. Cylindrical bone voids (10 ml) were created in the medial femoral...     »
Journal title abbreviation:
APMIS
Year:
2019
Journal volume:
127
Journal issue:
2
Pages contribution:
53-63
Fulltext / DOI:
doi:10.1111/apm.12918
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30698307
Print-ISSN:
0903-4641
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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