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Titel:

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Barrett, Tessa J; Schlegel, Martin; Zhou, Felix; Gorenchtein, Mike; Bolstorff, Jennifer; Moore, Kathryn J; Fisher, Edward A; Berger, Jeffrey S
Abstract:
Platelets are best known as mediators of hemostasis and thrombosis; however, their inflammatory effector properties are increasingly recognized. Atherosclerosis, a chronic vascular inflammatory disease, represents the interplay between lipid deposition in the artery wall and unresolved inflammation. Here, we reveal that platelets induce monocyte migration and recruitment into atherosclerotic plaques, resulting in plaque platelet-macrophage aggregates. In Ldlr-/- mice fed a Western diet, platele...     »
Zeitschriftentitel:
Sci Transl Med
Jahr:
2019
Band / Volume:
11
Heft / Issue:
517
Volltext / DOI:
doi:10.1126/scitranslmed.aax0481
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31694925
Print-ISSN:
1946-6234
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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