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Titel:

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gao, Yuanqing; Layritz, Clarita; Legutko, Beata; Eichmann, Thomas O; Laperrousaz, Elise; Moullé, Valentine S; Cruciani-Guglielmacci, Celine; Magnan, Christophe; Luquet, Serge; Woods, Stephen C; Eckel, Robert H; Yi, Chun-Xia; García-Cáceres, Cristina; Tschöp, Matthias H
Abstract:
Neuronal circuits in the brain help to control feeding behavior and systemic metabolism in response to afferent nutrient and hormonal signals. Although astrocytes have historically been assumed to have little relevance for such neuroendocrine control, we investigated whether lipid uptake via lipoprotein lipase (LPL) in astrocytes is required to centrally regulate energy homeostasis. Ex vivo studies with hypothalamus-derived astrocytes showed that LPL expression is upregulated by oleic acid, wher...     »
Zeitschriftentitel:
Diabetes
Jahr:
2017
Band / Volume:
66
Heft / Issue:
10
Seitenangaben Beitrag:
2555-2563
Volltext / DOI:
doi:10.2337/db16-1278
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28710138
Print-ISSN:
0012-1797
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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