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Titel:

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.

Dokumenttyp:
Journal Article
Autor(en):
Schriever, Sonja C; Zimprich, Annemarie; Pfuhlmann, Katrin; Baumann, Peter; Giesert, Florian; Klaus, Valentina; Kabra, Dhiraj G; Hafen, Ulrich; Romanov, Artem; Tschöp, Matthias H; Wurst, Wolfgang; Conrad, Marcus; Hölter, Sabine M; Vogt Weisenhorn, Daniela; Pfluger, Paul T
Abstract:
Elevated levels of oxidative stress and neuronal inflammation in the hypothalamus or ventral midbrain, respectively, represent common denominators for obesity and Parkinson's Disease (PD). However, little is known about defense mechanisms that protect neurons in these regions from oxidative damage. Here, we aimed to assess whether murine Gpx4, a crucial antioxidant enzyme that protects neurons from membrane damage and ferroptosis, is critical for the protection from neuronal inflammation in two...     »
Zeitschriftentitel:
Neuroscience
Jahr:
2017
Band / Volume:
357
Seitenangaben Beitrag:
241-254
Volltext / DOI:
doi:10.1016/j.neuroscience.2017.05.050
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28627418
Print-ISSN:
0306-4522
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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