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Titel:

Endothelial HIF-1? Enables Hypothalamic Glucose Uptake to Drive POMC Neurons.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Varela, Luis; Suyama, Shigetomo; Huang, Yan; Shanabrough, Marya; Tschöp, Matthias H; Gao, Xiao-Bing; Giordano, Frank J; Horvath, Tamas L
Abstract:
Glucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neurons. We show that endothelial hypoxia-inducible factor 1? (HIF-1?) controls glucose uptake in the hypothalamus and that it is upregulated in conditions of undernourishment, during which POMC neuronal activity is decreased. Endothelium-specific knockdown of HIF-1? impairs the ability of POMC neurons to adapt to the changing metabolic environment in vivo, resulting in overeating after food deprivation in mice. The impaire...     »
Zeitschriftentitel:
Diabetes
Jahr:
2017
Band / Volume:
66
Heft / Issue:
6
Seitenangaben Beitrag:
1511-1520
Volltext / DOI:
doi:10.2337/db16-1106
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28292966
Print-ISSN:
0012-1797
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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