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Title:

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.

Document type:
Journal Article
Author(s):
Schriever, Sonja C; Zimprich, Annemarie; Pfuhlmann, Katrin; Baumann, Peter; Giesert, Florian; Klaus, Valentina; Kabra, Dhiraj G; Hafen, Ulrich; Romanov, Artem; Tschöp, Matthias H; Wurst, Wolfgang; Conrad, Marcus; Hölter, Sabine M; Vogt Weisenhorn, Daniela; Pfluger, Paul T
Abstract:
Elevated levels of oxidative stress and neuronal inflammation in the hypothalamus or ventral midbrain, respectively, represent common denominators for obesity and Parkinson's Disease (PD). However, little is known about defense mechanisms that protect neurons in these regions from oxidative damage. Here, we aimed to assess whether murine Gpx4, a crucial antioxidant enzyme that protects neurons from membrane damage and ferroptosis, is critical for the protection from neuronal inflammation in two...     »
Journal title abbreviation:
Neuroscience
Year:
2017
Journal volume:
357
Pages contribution:
241-254
Fulltext / DOI:
doi:10.1016/j.neuroscience.2017.05.050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28627418
Print-ISSN:
0306-4522
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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