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Title:

TNF? drives mitochondrial stress in POMC neurons in obesity.

Document type:
Journal Article
Author(s):
Yi, Chun-Xia; Walter, Marc; Gao, Yuanqing; Pitra, Soledad; Legutko, Beata; Kälin, Stefanie; Layritz, Clarita; García-Cáceres, Cristina; Bielohuby, Maximilian; Bidlingmaier, Martin; Woods, Stephen C; Ghanem, Alexander; Conzelmann, Karl-Klaus; Stern, Javier E; Jastroch, Martin; Tschöp, Matthias H
Abstract:
Consuming a calorically dense diet stimulates microglial reactivity in the mediobasal hypothalamus (MBH) in association with decreased number of appetite-curbing pro-opiomelanocortin (POMC) neurons; whether the reduction in POMC neuronal function is secondary to the microglial activation is unclear. Here we show that in hypercaloric diet-induced obese mice, persistently activated microglia in the MBH hypersecrete TNF? that in turn stimulate mitochondrial ATP production in POMC neurons, promotin...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Pages contribution:
15143
Fulltext / DOI:
doi:10.1038/ncomms15143
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28489068
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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