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Titel:

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Dokumenttyp:
Journal Article
Autor(en):
Jall, Sigrid; Sachs, Stephan; Clemmensen, Christoffer; Finan, Brian; Neff, Frauke; DiMarchi, Richard D; Tschöp, Matthias H; Müller, Timo D; Hofmann, Susanna M
Abstract:
Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is typically first evaluated in male mouse models of diet-induced obesity (DIO). To address this disparity we herein determined whether a monomeric peptide with agonism at the receptors for glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon is equally efficient in correcting DIO, dyslipidemia, and glucose metabolism in D...     »
Zeitschriftentitel:
Mol Metab
Jahr:
2017
Band / Volume:
6
Heft / Issue:
5
Seitenangaben Beitrag:
440-446
Volltext / DOI:
doi:10.1016/j.molmet.2017.02.002
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28462078
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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