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Document type:
Journal Article
Author(s):
Wang, Lifeng; Sinnott-Armstrong, Nasa; Wagschal, Alexandre; Wark, Abigail R; Camporez, Joao-Paulo; Perry, Rachel J; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T; Soukas, Alexander; Avruch, Joseph; Fried, Susan K; Hauner, Hans; Sadreyev, Rusl...     »
Title:
A MicroRNA Linking Human Positive Selection and Metabolic Disorders.
Abstract:
Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity and type 2 diabetes in humans, raising the possibility that additional genetic elements in the locus may have contributed to evolutionary adaptation to famine by promoting energy storage, but which now confer susceptibility to metabolic diseases. We sho...     »
Journal title abbreviation:
Cell
Year:
2020
Journal volume:
183
Journal issue:
3
Pages contribution:
684-701.e14
Fulltext / DOI:
doi:10.1016/j.cell.2020.09.017
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33058756
Print-ISSN:
0092-8674
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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