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Title:

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Author(s):
Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C
Abstract:
Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. In this study, we show in a murine scald injury model that T cell activation of both CD4+ and CD8+ T cells as well as T cell cytokine production is suppressed acutely and p...     »
Journal title abbreviation:
Front Immunol
Year:
2020
Journal volume:
11
Fulltext / DOI:
doi:10.3389/fimmu.2020.00876
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32477354
Print-ISSN:
1664-3224
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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